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Type of Hyperbilirubinemia location and Cause Unconjugated hyperbilirubinemia Increased bilirubin manufacturing (eg, hemolytic anemias, hemolytic reactions, hematoma, pulmonary infarction) (predominantly indirect Impaired bilirubin uptake and storage (eg, posthepatitis hyperbilirubinemia, Gilbert syndrome, Crigler� bilirubin) Najjar syndrome, drug reactions) Conjugated hyperbilirubinemia Hereditary Cholestatic Syndromes (see also Table 16-2) (predominantly direct Faulty excretion of bilirubin conjugates (eg, Dubin-Johnson syndrome, Rotor syndrome) or mutation in bilirubin) genes coding for bile salt transport proteins (eg, progressive familial intrahepatic cholestasis syndromes, benign recurrent intrahepatic cholestasis, and some circumstances of intrahepatic cholestasis of being pregnant) Hepatocellular Dysfunction Biliary epithelial and hepatocyte injury (eg, hepatitis, hepatic cirrhosis) Intrahepatic cholestasis (eg, sure medicine, biliary cirrhosis, sepsis, postoperative jaundice) Hepatocellular harm or intrahepatic cholestasis resulting from miscellaneous causes (eg, spirochetal infections, infectious mononucleosis, cholangitis, sarcoidosis, lymphomas, industrial toxins) Biliary Obstruction Choledocholithiasis, biliary atresia, carcinoma of biliary duct, sclerosing cholangitis, choledochal cyst, exterior stress on bile duct, pancreatitis, pancreatic neoplasms Table sixteen-2 menstrual disorders order alendronate us. 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